Keluarga Kabisote

• Vic Sotto as Enteng Kabisote
• Aiza Seguerra as Aiza Kabisote
• Oyo Boy Sotto as Benok Kabisote
• Amy Perez as Ina Magenta
• Bing Loyzaga as Satana/Amarillo
• Ruby Rodriguez as Amy
• Jose Manalo as Bodyguard Jose
• Mikylla Ramirez as Ada Kabisote
• Gwen Zamora as Faye Kabisote
• Wally Bayola as Bodyguard Boggart
• Paolo Ballesteros as Gay Lover
• Pauleen Luna as Sexy Waitress
• Megan Young as Ina Azul
• Precious Lara Quigaman as Ina Berde
• Fritz Ynfante as Doctor Fairy
• Ciara Sotto as Trainors
• Gian Sotto
• Janice Hung as Ether
• Wahoo Sotto
• Jerome Galica
• Gerard Acao as Mariahouit
• Thou Reyes as Danolla

Keluarga Montecillo

• Ai-Ai delas Alas as Ina Montecillo
• Marvin Agustin as Juan Montecillo
• Nikki Valdez as Getrudis "Tudis" Montecillo
• Carlo Aquino as Dimitri "Tri" Montecillo
• Alwyn Uytingco as Tirso "Pip" Montecillo
• Xyriel Manabat as Monay Montecillo
• Eugene Domingo as Rowena (undangan khas)[5]
• Owie Boy Gapuz as Ogie Boy Montecillo
• Jon Avila as Frank
• Heart Evangelista as Portia "Por" Montecillo (dimaksudkan sahaja)
• Empoy Marquez as William (suami Seven)
• Cecil Paz as Malena
• Shaina Magdayao as Severina "Seven" Montecillo (dimaksudkan sahaja)
• Erika Padilla as Nora
• Piolo Pascual as PSG Carlito